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Fischer, S. (2016): Single-step scaffold-based cartilage repair in the knee. Decision Support Document 98.

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In this report, we analysed whether single-step scaffold-based cartilage repair in combination with microfracturing (MFx) is more effective and safe in comparison to microfracturing alone, or as effective but safer in comparison to (matrix-induced) autologous chondrocyte implantation.

In total, data from three controlled trials that met our inclusion criteria were extracted. It appears that single-step scaffold-assisted cartilage repair in combination with MFx leads to similar short to medium-term (up to five years follow-up) results, compared to MFx alone. Overall, the strength of the evidence was low.

At the moment, it seems too early to include single-step scaffold-assisted cartilage repair of the knee in the Austrian catalogue of benefits. A re-evaluation is recommended for 2018 at the earliest.

Item Type:Decision Support Document
Keywords:Cartilage defects, microfracturing, autologous chondrocyte implantation, chondrogenesis, AMIC
Subjects:WB Practice of medicine > WB 300-962 Therapeutics
W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WE Musculoskeletal system > WE 300-400 Joint tissues
WE Musculoskeletal system > WE 168-190 Orthopedics
WE Musculoskeletal system > WE 800-890 Extremities and podiatry
Series Name:Decision Support Document 98
Deposited on:14 Jul 2016 21:48
Last Modified:15 Jul 2020 17:54

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