AIHTA - Publications - Search - Percutaneous coronary interventions (PCI) for chronic total occlusion (CTO). Update 2022

Semlitsch, T. and Zipp, C. and Loder, C. (2022): Percutaneous coronary interventions (PCI) for chronic total occlusion (CTO). Update 2022. Decision Support Document 64/ Update 2022.

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The therapeutic goal of percutaneous coronary intervention (PCI) in patients with chronic total occlusion (CTO) is to relieve symptoms and improve quality of life, avoid cardiac sequelae and more invasive coronary artery bypass grafting (CABG), and prolong life.

The evidence (6 RCTs, n=1,911) indicates that PCI for CTO is more effective and as safe as optimal medical therapy (OMT) alone in terms of alleviating angina pectoris symptoms and improving quality of life. An adequate safety profile of PCI in CTO was further confirmed by four cohort studies (n=3,593). However, compared with CABG, the evidence from one RCT (n=460) and two cohort studies (n=3,025) is insufficient to draw conclusions on comparative efficacy and safety. There are currently five ongoing trials, none of which compare PCI with CABG in CTO.

Item Type:Decision Support Document
Keywords:Percutaneous coronary interventions, chronic total occlusion, coronary artery disease
Subjects:W Health professions > W 100-275 Medical, dental and pharmaceutical service plans
WB Practice of medicine > WB 300-962 Therapeutics
WG Cardiovascular system
WO Surgery > WO 500-517 Operative surgical procedures. Techniques
Series Name:Decision Support Document 64/ Update 2022
Deposited on:15 Jul 2022 09:20
Last Modified:15 Jul 2022 09:20

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